In people with heart disease, depression is more likely to lead to heart attack, stroke and chest pain than is smoking, high blood pressure or even diabetes. But the odds can be evened by taking antidepressants known as selective serotonin reuptake inhibitors SSRIs, according to a Canadian study published in the Journal of the American Medical Association. Having low levels of serotonin is associated with depression, so “reuptake inhibitors,” by keeping more serotonin available to the brain, may relieve depression. These medications are safe for heart patients and work well for many. According to the Journal study, SSRIs are more effective than interpersonal psychotherapy in improving depression in heart patients. During the first few weeks of taking an SSRI, patients may actually experience increased anxiety until the drug is fully effective — usually in 4 to 6 weeks. Adverse effects that may last throughout the time the medication is taken include sexual difficulties, nausea, and headache. Some SSRIs, when paired with the antibiotic erythromycin, can increase the risk of irregular heartbeat or sudden death.
Back to Medication. This news, which was reported well by the BBC was based on good quality research into the relationship between the electrical activity of the heart and use of antidepressant medication. Other SSRI antidepressants were included in the study as well. They found that some of the drugs being studied were associated with a disturbance of the electrical activity of the heart, which increased at higher doses of the medication. While these changes in the electrical activity of the heart represent a theoretical increase in the risk of serious heart rhythm problems, such events are quite rare. Doctors are already aware that these drugs carry this potential risk. As a result, new recommendations about antidepressant dosage were released in
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