Other researchers may extract the data from the CPRD database and replicate the analysis, provided they have appropriate governance procedures and ethical approvals. Interested researchers may contact the CPRD directly kc cprd. Cardiovascular disease CVD is a common comorbidity in people with asthma. However, safety concerns have caused heterogeneity in clinical guideline recommendations over the use of cardioselective beta-blockers in people with asthma and CVD, partly because risk in the general population has been poorly quantified. The aim of this study was to measure the risk of asthma exacerbations with beta-blockers prescribed to a general population with asthma and CVD. Linked data from the UK Clinical Practice Research Datalink was used to perform nested case-control studies among people with asthma and CVD matched on age, sex and calendar time. Adjusted incidence rate ratios IRR were calculated for the association between oral beta-blocker use and moderate asthma exacerbations rescue oral steroids or severe asthma exacerbations hospitalisation or death using conditional logistic regression. The cohort consisted of 35, people identified with active asthma and CVD, of which
Randomized placebo-controlled trial to evaluate chronic dosing effects of propranolol in asthma. Authors randomized 18 patients taking inhaled corticosteroids for mild to moderate asthma to receive propranolol up to 80 mg or placebo for weeks in a crossover design study. In others, newer drug options may be more appropriate. View all 23 references. Cardioselective beta-blockers may reduce forced expiratory volume FEV1. Ann Intern Med. Visken pindolol.
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Health-System Edition. Beta-blocker use and incidence of chronic obstructive pulmonary disease exacerbations. The study how to treat diabetes why randomized, double-blind, three-period, crossover, placebo-controlled trial with at least a 7-day washout phase between treatment periods. Comparison propranolol respiratory effects of two cardioselective beta-blockers, celiprolol and atenolol, in asthmatics with mild to moderate hypertension. On the other hand, a recent placebo-controlled trial of propranolol take tiotropium bromide added to inhaled corticosteroids revealed no effect on with hyperresponsiveness and a small, not statistically significant, fall in FEV 1 in can classified as having mild to moderate asthma. Asthma, not all types hake beta-blocker exposure could be properly assessed, you acute high dose non-selective beta-blocker exposure were risk is likely to be greater. Med Arch.