The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR Published : 20 August Also, significant interactions between age and diet should be noted to evaluate the effects of these two variables on microbial composition. Effect of high fat diet and time course of feeding on the composition of gut microflora. Download references. Author manuscript; available in PMC Sep 1. Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation. Ismail, L.
Numerous studies have suggested that the composition of the gut microbiota differs between obese and normal weight individuals [ 18, 19, 20 ]. Gastric microbiota: tracing the culprit. Brooks, E. The mechanisms that link obesity to disease risk are undoubtedly multifactorial in origin. Further, HFD can alter intestinal barrier structure via a reduction of tight junction proteins The data indicated a pattern of reduced expression of these antimicrobial peptides corresponding to the changes of gut microflora as early as 8 weeks of HF feeding Figure 3. Microbes doi: Received : 27 September
This review will examine the recent scientific literature surrounding high-fat-diet HFD -induced alterations in gut microbiota and subsequent development of obesity and chronic disease risk. Excessive consumption of HFDs has undoubtedly contributed to the obesity epidemic. However, the mechanisms responsible for this relationship are likely to be more complex than the simple concept of energy balance. In fact, emerging literature has implicated HFD-induced alterations in gut microbiota in the obesity epidemic. HFD consumption generally leads to a decrease in Bacteroidetes and an increase in Firmicutes, alterations that have been associated with obesity and subsequent development of chronic diseases. Potential mechanisms for this effect include 1 an improved capacity for energy harvest and storage and, 2 enhanced gut permeability and inflammation.